COSTA, EUNICE,TEMTEM, MARCIO,SOBRAL, LUIS,CACELA, CONSTANCA,VILLAX, PETER
申请号：
CA2938071
公开号：
CA2938071A1
申请日:
2015.01.27
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents； (ii) particle size reduction of the suspension； (iii) aging； (iv)stopping the aging by solvent removal； and (v) optionally, a step of isolating the processed ingredients in the form of powder.
