Costa, Eunice,Temtem, Marcio,Sobral, Luis,Cacela, Constanca,Villax, Peter
申请号:
AU2015212618
公开号:
AU2015212618A1
申请日:
2015.01.27
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
A new scalable process to control the particle size and the particle size distribution, comprising5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv)stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.