A new scalable process to control the particle size and the particle size distribution, comprising 5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents； (ii) particle size reduction of the suspension； (iii) aging； (iv) stopping the aging by solvent removal； and (v) optionally, a step of isolating the processed ingredients in the form of powder.
