A thrombectomy and balloon angioplasty catheter for the removal of blood clots and debris from a blood vessel and/or for the dilation of a narrowed or completely closed segment in the blood vessel is disclosed. The catheter includes a shaft having a proximal end and a distal end, an angioplasty balloon mounted to the shaft adjacent the distal end of the shaft, and an occlusion balloon mounted to the shaft at a location proximally spaced from the angioplasty balloon. A guide wire lumen is arranged on the shaft. The guide wire lumen extends from a first position adjacent the distal end of the shaft to a second position proximal the angioplasty balloon and distal the proximal end of the shaft. The shaft includes an angioplasty balloon inflation lumen in fluid communication with the proximal end of the shaft and an interior space of the angioplasty balloon, an occlusion balloon inflation lumen in fluid communication with the proximal end of the shaft and an interior space of the occlusion balloon, and a thrombectomy lumen in fluid communication with the proximal end of the shaft and a thrombectomy suction port located between the angioplasty balloon and the occlusion balloon.
