To provide a highly safe silver-based antimicrobial composition that exhibits antimicrobial property early in accord with the decomposition and absorption of calcium compound after a bone regeneration material is implanted in the body and that yet has a low risk of developing cytotoxicity.SOLUTION: By mixing a calcium acetate solution and a silver nitrate solution to generate a white precipitate, followed by adding thereto nitric acid to dissolve and prepare a sample solution, followed by subjecting to ultrasonic spray pyrolysis to produce a hollow approximately spherical calcium carbonate particle in which silver nanoparticles are distributed and deposited approximately homogeneously on the surface, and thereby an antimicrobial inorganic filler is obtained.SELECTED DRAWING: Figure 4【課題】骨再生材料が体内にインプラントされた後カルシウム化合物の分解吸収に伴い抗菌性を早期に発揮し、尚且つ細胞毒性を発現する恐れの少ない安全性の高い銀系抗菌性組成物を提供する。【解決手段】酢酸カルシウム溶液と硝酸銀溶液を混合して生成した白色沈殿に硝酸を加えることで溶解して調製した試料溶液を超音波噴霧熱分解することによって銀ナノ粒子が表面に略均質に分布して析出した中空略球状の炭酸カルシウム粒子を製造し、抗菌性無機フィラーとする。【選択図】図４
