Connolly, Michael D.,Timoteo, Gulliver,Gao, Man,Peretz, David,Shimizu, Robert M.,Zuckermann, Ronald
申请号：
AU2006287299
公开号：
AU2006287299B2
申请日:
2006.09.08
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to peptoid reagents that interact preferentially with apathogenic form of a conformational disease protein as compared to a nonpathogenic formof the conformational disease protein where the peptoid reagent comprises anamino-terminal region, a carboxy-terminal region, and at least one peptoid regionbetween the amino-terminal region and the carboxy-terminal region where thepeptoid region comprises 3 to about 30 N-substituted glycines, and optionally oneor more amino acids. The invention also relates to methods of using the peptoids indetecting and isolating prions, and in the treatment and prevention of prion-related diseases.
