WILLIAMS, ROBERT O., III,JOHNSTON, KEITH P.,SINSWAT, PRAPASRI,MCCONVILLE, JASON T.,TALBERT, ROBERT,PETERS, JAY,WATTS, ALAN B.,ROGERS, TRUE L.
申请号：
CA3027598
公开号：
CA3027598C
申请日:
2008.01.10
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non- polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
