Merck Sharp & Dohme Corp.;The Walter and Eliza Hall Institute of Medical Research
发明人:
KHAN, Tanweer, A.,CUMMING, Jared, N.,OLSEN, David, B.,BODDEY, Justin, A.,COWMAN, Alan, F.,SLEEBS, Brad, E.
申请号：
EP17753680
公开号：
EP3416647A4
申请日:
2017.02.13
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention provides methods of treating malaria comprising administration of an N3-substituted iminopyrimidinone of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables R1, R2, R3, R4, R5, A, B, L, m, and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
