Merck Sharp &； Dohme Corp.;The Walter and Eliza Hall Institute of Medical Research
发明人:
Tanweer A. Khan,Jared N. Cumming,David B. Olsen,Justin A. Boddey,Alan F. Cowman,Brad E. Sleebs
申请号：
US16076400
公开号：
US20200230140A1
申请日:
2017.02.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides methods of treating malaria comprising administration of an N3-substituted iminopyrimidinone of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables R1, R2, R3, R4, R5, A, B, L, m, and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
