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ADMINISTRATION AMELIOREE DE COMPOSITIONS MEDICAMENTEUSES IMMUNOSUPPRESSIVES PAR VOIE PULMONAIRE
专利权人:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;THE DOW CHEMICAL COMPANY
发明人:
申请号:
EP08780367.2
公开号:
EP2124898B1
申请日:
2008.01.10
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
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