The disclosure provides, among other things, compositions that bind to and inhibit the biological activity of soluble biomolecules, as well as pharmaceutical compositions thereof. The compositions may comprise a plurality of particles that specifically bind a target, such as a soluble biomolecule or a biomolecule on the surface of a pathogen, to inhibit the target (or pathogen) from interacting with other molecules or cells. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.本發明提供結合於可溶性生物分子且抑制其生物活性之組合物,以及其醫藥組合物。該等組合物可包含特異性結合標靶(諸如可溶性生物分子或病原體表面上之生物分子)以抑制該標靶(或病原體)與其他分子或細胞相互作用的複數個顆粒。本發明亦提供該等組合物適用之多種應用(例如治療性應用)。