METHODS AND MATERIALS FOR USING TRANSGENIC NON-HUMAN ANIMALS EXPRESSING SODIUM IODIDE SYMPORTER POLYPEPTIDES TO MONITOR PATHOLOGICAL PROCESSES, DISEASE PROGRESSION, OR THERAPEUTIC RESPONSES OVER TIME
Mayo Foundation for Medical Education and Research
发明人:
Peng Kah-Whye,Russell Stephen James,Lech Patrycja,Suksanpaisan Lukkana
申请号：
US201615566827
公开号：
US2018103620(A1)
申请日:
2016.04.15
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
This document provides methods and materials for using live transgenic non-human animals (e.g., non-human mammals) to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time. For example, methods and materials for using live transgenic non-human animals (e.g., non-human mammals) having somatic and germline cells that include nucleic acid (e.g., a transgene) having a promoter sequence operably linked to a nucleic acid sequence encoding a NIS polypeptide to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time are provided.
