METHODS AND MATERIALS FOR USING TRANSGENIC NON-HUMAN ANIMALS EXPRESSING SODIUM IODIDE SYMPORTER POLYPEPTIDES TO MONITOR PATHOLOGICAL PROCESSES, DISEASE PROGRESSION, OR THERAPEUTICRESPONSES OVER TIME
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人:
PENG, KAH-WHYE,RUSSELL, STEPHEN JAMES,LECH, PATRYCJA,SUKSANPAISAN, LUKKANA
申请号：
CA2982994
公开号：
CA2982994A1
申请日:
2016.04.15
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This document provides methods and materials for using live transgenic non-human animals (e.g., non-human mammals)to perform radiotracer imaging to monitor pathological processes, diseaseprogression, or therapeutic responses in vivo overtime. For example, methods and materials for using live transgenic non-humananimals (e.g., non-human mammals) having somaticand germline cells that include nucleic acid (e.g., a transgene) having apromoter sequence operably linked to a nucleic acid sequenceencoding a NIS polypeptide to perform radiotracer imaging to monitorpathological processes, disease progression, or therapeuticresponses in vivo over time are provided.
