The present invention relates to the induction of tolerance to antigens, bymucosal, preferably oral delivery of the antigen in combination with animmunomodulating compound producing micro-organism. More specifically, theinvention relates to the induction of Foxp3+ and/or IL-10 and/or TGF-.beta.producing regulatory T-cells, capable of suppressing undesired immuneresponses toward an antigen, by oral delivery of said antigen in combinationwith an immunosuppressing cytokine secreting micro-organism.