This invention relates to pharmaceutical formulations for topical skin application comprising (R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl] propanenitrile, or a pharmaceutically acceptable salt thereof, and use in the treatment of skin disorders.本發明涉及局部皮膚應用的藥物製劑以及在治療皮膚疾患中的用途,所述藥物製劑包含(R)-3-環戊基-3-[4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基]丙腈或其藥學上可接受的鹽。