Provided herein are compositions and methods for the treatment of a hematological malignancy. Also disclosed herein are compositions and methods for the treatment of Ewing's sarcoma. Said methods comprise the administration of isoform selective pyrrolo-pyrazole PKC inhibitors and CAR-T therapy.本文提供用於治療血液惡性病之組合物及方法。本文亦揭示用於治療尤文氏肉瘤(Ewing's sarcoma)之組合物及方法。該等方法包含投與同功異型物選擇性吡咯并-吡唑PKC抑制劑及CAR-T療法。