FIELD: medicine, psychiatry. ^ SUBSTANCE: in case of available somatic pathology and decreased content of natural killers up to 8% and lower and phagocytic activity of leukocytes up to 60% and lower one should predict prolonged flow of depressive reactions. The method enables to predict the flow of depressive reactions at early stages and apply purposefully certain rehabilitation psychotherapeutic and pharmacological procedures. ^ EFFECT: higher efficiency of prediction. ^ 2 ex, 2 tbl