Michael Thompson,Sonia Sheikh,Jack Chih-Chieh Sheng,Christophe Blaszykowski,Kiril Fedorov
申请号：
US13935526
公开号：
US09078956B2
申请日:
2013.07.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A surface-modified polymer is described, comprising a polymeric material and a self-assembling monolayer covalently bound thereto. The monolayer comprises monoethylene glycolated-OH (MEG-OH) 2-(3-trichlorosilyl-propyloxy)-ethyl-trifluoroacetate (7-OEG or MEG-TFA) 2,2,2-trifluoroethyl-13-trichlorosilyl-tridecanoate (TTTA) OEGylated TTTA (OEG-TTTA) S-(2-(2-(2-(3-trichlorosilyl-propyloxy)-ethoxy)-ethoxy)-ethyl)-benzenethiosulfonate (OEG-TUBTS) or a combination thereof. Methods are described for forming a surface-modified polymer by surface activation, such as with plasma. By utilizing the surface-modified polymer to make medical equipment or devices for contacting biological fluids, a reduction in surface fouling and thrombus formation can result. Advantageously, polymeric equipment or components so modified may have a reduction in unwanted chemical interactions leading to fouling or clotting. Short trichlorosilane surface modifiers allow films to be deposited onto poly(ethylene terephthalate), polycarbonate, polypropylene, polyvinyl chloride, polyurethane, and other polymers activated using plasma.
