synergistic composition of nitazoxanide and mebendazole, processes for its preparation and use of said composition for the treatment of human parasitosis
Patent Summary for: "Synergistic composition of nitazoxanide and mebendazole, processes for preparing it and use of said composition for treating human parasitosis." The present invention relates to a synergistic pharmaceutical composition for treating human parasites of mebendazole. (mbdz) with nitazoxanide (ntzx), which significantly broadens the spectrum of mbdz against protozoans and enhances the anthelmintic action of ntzx. In addition, by using the pharmaceutical combination of mbdz and ntzx, the systemic action of the active metabolite of ntzx, tizoxanide, and the treatment of some systemic forms of parasitosis maintains the same effects as individual active principles. Also, the synergistic pharmaceutical combination of mbdz with ntzx achieves a broader antiparasitic spectrum, while maintaining the efficacy and safety profiles of both active ingredients separately. All of these effects allow the pharmaceutical combination of the present invention to differ from the rest of the classical antiparasitic treatments having more limited spectra. The synergistic effects of the pharmaceutical combination mbdz and ntzx are therefore the main object of the present invention. 1/1resumo da patente de invenção para: “composição sinérgica de nitazoxanida e mebendazol, processos para preparação da mesma e uso da dita composição para tratamento de parasitose humana.” a presente invenção se refere a uma composição farmacêutica sinérgica para o tratamento de parasitose humana de mebendazol (mbdz) com nitazoxanida (ntzx), que amplia significativamente o espectro do mbdz contra protozoários e reforça a ação anti-helmíntica da ntzx. além disso, ao usar a combinação farmacêutica de mbdz e ntzx, a ação sistêmica do metabolito ativo da ntzx, a tizoxanida, e o tratamento de algumas formas sistêmicas de parasitose, mantém os mesmos efeitos dos princípios ativos individuais. também, a combinação farmacêutica sinérgica de mbdz com ntzx consegue um maior espectro antiparasitário, enquan
