ZAK, Mark,GOODACRE, Simon Charles,CHENG, Limin,ROMERO, F. Anthony,CHENG, Yun-Xing,HUA, Rongbao
申请号：
PE2019000482
公开号：
PE20190632A1
申请日:
2017.09.02
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
It refers to the pyridine of formula (I) or (II) of compound 8 - (azerbaijan-1-il) - [1.2.4] trinitroformic acid [1.5-A], wherein ring a is phenyl, pyridine, pyridinediene or isoquinol； ring B is isopropyl of phenyl or 5-6 elements； n is 0, 1 or 2； R2 es-c (o) - NH - (C1-C6 tar, optionally replaced by halogen, Oh or CN),Among other things, R3, R4 and R5 are all h, CH3 and ch2ch3； R6 is h or C1-C3 tar； R1a is halogenated carbon, and C1-C6 tar can optionally be replaced by halogenated carbon, CN or Oh, Alcoy C1-C6； r1b and r1c are added together to form 3 to 10 heterocyclic chemicals that can optionally be replaced by C1-C6 tar. 2 - [2]]]]]] - [1 - [1 - [1 - [3 - [3 - [3 - [3]]]] erazin-1-il) - 2-oxo-ethi] pirazol-4-il] amine] - [1, 2, 4] triazolo [1, 5-a] pyridine-8-il [azerbaijan-3-il] acetone；There are others He also mentioned a pharmaceutical composer These compounds are inhibitors of JAK 500 sleeping pills, which are used to treat asthma.SE REFIERE A COMPUESTOS 8-(AZETIDIN-1-IL)-[1,2,4]TRIAZOLO[1,5-A]PIRIDINILO DE FORMULA (I) O (II) DONDE EL ANILLO A ES FENILO, PIRIDINILO, PIRAZOLILO O ISOQUINOLINILO； EL ANILLO B ES FENILO O HETEROARILO DE 5-6 ELEMENTOS； n ES 0, 1 O 2； R2 ES -C(O)-NH-(ALQUILO C1-C6 SUSTITUIDO OPCIONALMENTE CON HALOGENO, OH O CN), ENTRE OTROS； R3, R4 Y R5 SON CADA UNO H, CH3, CH2CH3, ENTRE OTROS； R6 ES H O ALQUILO C1-C3； R1a ES HALOGENO, ALQUILO C1-C6 SUSTITUIDO OPCIONALMENTE CON HALOGENO, CN O OH, ALCOXI C1-C6, ENTRE OTROS； R1b Y R1c JUNTOS FORMAN UN HETEROCICLOALQUILO DE 3 A 10 ELEMENTOS SUSTITUIDO OPCIONALMENTE CON ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-[3-(4-ETIL-1H-PIRAZOL-1-IL)-1-[2-([1-[2-(4-METILPIPERAZIN-1-IL)-2-OXOETIL]-1H-PIRAZOL-4-IL]AMINO)-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-8-IL]AZETIDIN-3-IL]ACETONITRILO； 2-[3-(4,4-DIFLUORO-1-PIPERIDIL)-1-[2-[[1-[2-(4-METILPIPERAZIN-1-IL)-2-OXO-ETIL]PIRAZOL-4-IL]AMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-8-IL]AZETIDIN-3-IL]ACETONITRILO； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACE
