Compounds of Formula I:or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, halogenated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided. Pharmaceutical compositions comprising a compound of formula I and a compound of Formula II:or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof. Compositions and methods for improving the efficacy of DEX, or providing beneficial pharmacokinetic effects to DEX, comprising co-administering a compound of formula I or SARPO, and a compound of Formula II or DEX to a subject in need thereof, and dosage forms, drug delivery systems, methods of treatment thereof.提供了式I化合物:或其鏡像異構物、其代謝物、其衍生物、其氘化衍生物、其鹵化衍生物、其前驅藥、其藥學上可接受之鹽、其N-氧化物、或其組合、其製備所用的方法與中間物、其組成物、以及其用途。藥學組成物,包含式I化合物與式II化合物:或其鏡像異構物、其代謝物、其衍生物、其氘化衍生物、其前驅藥、其藥學上可接受之鹽、其N-氧化物、或其組合。用於改善DEX功效、或對DEX提供有益的藥物動力學效應的組成物與方法,包含共同投予式I化合物或SARPO、和式II化合物或DEX至對其有需求的個體,以及其劑型、藥物投遞系統、治療方法。
