The present invention relates to compositions and methods useful for symptomatic and disease modifying treatments and therapies. A compound of formula I (I), or an enantiomer thereof, a metabolite thereof, a derivative thereof, a deuterated derivative thereof, a halogenated derivative thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof, N-oxides, or combinations thereof, methods and intermediates for their preparation, compositions thereof, and uses thereof are provided. Compounds of formula I and compounds of formula II: (IIa) (IIb), or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, A pharmaceutical composition comprising an N-oxide, or a combination thereof. A pharmacokinetic effect beneficial to DEX, including improving the efficacy of DEX, including co-administration of a compound of formula I or SARPO and a compound of formula II or DEX to a subject in need thereof Compositions and methods for providing, as well as dosage forms, drug delivery systems, and therapeutic methods. [Selection] Figure 4【課題】対症的及び疾患修飾処置及び治療法に有用な組成物及び方法に関する。【解決手段】式Ｉ（Ｉ）の化合物、若しくはその鏡像異性体、その代謝産物、その誘導体、その重水素化誘導体、そのハロゲン化誘導体、そのプロドラッグ、その薬学的に許容可能な塩、そのＮ－酸化物、又はそれらの組み合わせ、その調製のための方法及び中間体、その組成物、及びその使用が提供される。式Ｉの化合物及び式の化合物ＩＩ：（ＩＩａ）（ＩＩｂ）、若しくはその鏡像異性体、その代謝産物、その誘導体、その重水素化誘導体、そのプロドラッグ、その薬学的に許容可能な塩、そのＮ－酸化物、又はそれらの組み合わせを含む医薬組成物。式Ｉの化合物又はＳＡＲＰＯ、及び式ＩＩの化合物又はＤＥＸをそれを必要とする対象に同時投与することを含む、ＤＥＸの有効性を改善するための、又はＤＥＸに有益な薬物動態学的効果を提供するための組成物及び方法、並びにその剤形、薬物送達系、治療法。【選択図】図４
