EXCIVA UG (HAFTUNGSBESCHRANKT);VEPACHEDU, SREENIVASARAO
发明人:
VEPACHEDU, SREENIVASARAO,MOEBIUS, HANS J.,BESPALOV, ANTON
申请号：
CA3034895
公开号：
CA3034895A1
申请日:
2017.08.25
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Compounds of formula I, (I) or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, halogenated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N- oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided. Pharmaceutical compositions comprising a compound of formula I and a compound of Formula II: (IIa) (IIb) or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof. Compositions and methods for improving the efficacy of DEX, or providing beneficial pharmacokinetic effects to DEX, comprising co-administering a compound of formula I or SARPO, and a compound of Formula II or DEX to a subject in need thereof, and dosage forms, drug delivery systems, methods of treatment thereof.
