The disclosure provides for the addition of at least one amino acid residue such that the addition or deletion of at least one amino acid residue from the ABD eliminates the interaction between the existing antibody and the ABD without interfering with the binding of the ABD to its target. Or relates to an antigen binding domain (ABD) comprising a C-terminal modification, a N-terminal modification, or a C + N-terminal modification including a deletion.本開示は、ABDに対する少なくとも１のアミノ酸残基の付加または欠失がABDのその標的との結合を妨げることなく既存抗体とABDとの相互作用を排除するように少なくとも１のアミノ酸残基の付加または欠失を含むC末端修飾、N末端修飾、またはC＋N末端修飾を含む抗原結合ドメイン(ABD)に関する。
