BURKE, Martin D.,THOTTUMKARA, Arun P.,MELLEM, Kevin T.,SWEENEY, Zachary K.,KOLTUN, Elena S.
申请号：
HK18103742.5
公开号：
HK1244248A
申请日:
2018.03.18
申请国别(地区):
HK
年份:
2018
代理人:
摘要：
Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas, carbamates, and amides according to Formula (I)； C3′-substituted C16 ureas, carbamates, and amides according to Formula (II)； C16 acyls according to Formula (III)； C2′epi-C16 ureas, carbamates, and amides according to Formula (IV)； and C16 oxazolidinone derivatives according to Formula (V). Also disclosed are pharmaceutical compositions comprising the AmB derivatives, and therapeutic methods of using the AmB derivatives.
