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兩性黴素B的衍生物
专利权人:
Inc.;Sfunga Therapeutics
发明人:
BURKE, Martin D.,THOTTUMKARA, Arun P.,MELLEM, Kevin T.,SWEENEY, Zachary K.,KOLTUN, Elena S.
申请号:
HK18103742.5
公开号:
HK1244248A
申请日:
2018.03.18
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas, carbamates, and amides according to Formula (I); C3′-substituted C16 ureas, carbamates, and amides according to Formula (II); C16 acyls according to Formula (III); C2′epi-C16 ureas, carbamates, and amides according to Formula (IV); and C16 oxazolidinone derivatives according to Formula (V). Also disclosed are pharmaceutical compositions comprising the AmB derivatives, and therapeutic methods of using the AmB derivatives.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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