The Board of Trustees of The University of Illinois
发明人:
Burke, Martin D.,Davis, Stephen,Uno, Brice E.,Struble, Justin,Dailey, Ian,Gray, Kaitlyn C.,Knapp, David M.,Wang, Pulin,Palyam, Nagarjuna
申请号：
AU2019279928
公开号：
AU2019279928B2
申请日:
2019.12.09
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2019279928B220200723.pdf#####Attorney Docket No. UIX-014.25 ABSTRACT Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives ofAmB. Certain of the derivatives are C3, C5, C8, C9, C1I, C13, or C15 5 deoxy derivatives of AmB. Certain of the derivatives include C3'or C4' modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention. - 65-1/33 Figure 1 OH OH HO OH OH OHOHOH HO /'MeO OH OH OH OH O,,,,16R OR' 0 Me amphotericin B (AmB) COOH OH OH NH 2 0 Me amphotericin B methyl ester (AmBME) COOMe OH OH NH 2 amphoternolide (AmdeB) COOH H 0 Me C2'deoxy amphotericin B (C2'deOAmB) COOH OH NH 2
