The Board of Trustees of the University of Illinois
发明人:
Martin D. Burke,Stephen Davis,Brice E. Uno,Justin Struble,Ian Dailey,Kaitlyn C. Gray,David M. Knapp,Pulin Wang,Nagarjuna Palyam
申请号：
US16530109
公开号：
US20200002368A1
申请日:
2019.08.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′； or C4′； modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
