BURKE, MARTIN D.,THOTTUMKARA, ARUN P.,MELLEM, KEVIN T.,SWEENEY, ZACHARY K.,KOLTUN, ELENA S.
申请号：
CA3021061
公开号：
CA3021061A1
申请日:
2016.04.15
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed are derivatives of amphotericin B (AmB) characterized by improvedtherapeutic index compared to AmB.The AmB derivatives include C16 ureas, carbamates, and amides according toFormula (I)； C3' -substituted C16 ureas, carbamates,and amides according to Formula (II)； C16 acyls according to Formula (III)；C2'epi-C16 ureas, carbamates, and amides according toFormula (IV)； and C16 oxazolidinone derivatives according to Formula (V). Alsodisclosed are pharmaceutical compositionscomprising the AmB derivatives, and therapeutic methods of using the AmBderivatives.
