Provided herein is certain imidazopyrazines and its pharmaceutical compositions. The method of offer treatment patient, for the patient with the disease and illness for inhibiting to have response active to Syk, the method includes at least one chemical entity a effective amount of to sick note of the ancient Chinese or symptom for reducing the disease or illness is administered to such patient. Also offer determines the method that whether there is Syk kinases in sample with what.本文提供某些咪唑并哌嗪及其藥物組合物。提供治療患者的方法，所述患者患有對Syk活性的抑制具有應答的疾病和病症，所述方法包括向這樣的患者給藥對減少所述疾病或病症的病徵或症狀有效量的至少一種化學個體。還提供用於確定樣品中是否存在Syk激酶的方法。
