It provides and inhibits the pyrazine compounds of Syk kinases with what, the intermediate of such compound is prepared with what, their preparation method, its pharmaceutical composition, inhibiting the method for Syk kinase activities and the method for the illness at least partly mediated by Syk kinase activities with what treatment with what.提供了用於抑制Syk激酶的吡嗪類化合物、用於製備此類化合物的中間體、它們的製備方法、其藥物組合物、用於抑制Syk激酶活性的方法以及用於治療至少部分由Syk激酶活性介導的疾患的方法。