Songping D. Huang,Yongxiu Li,Mohammadreza Shokouhimehr
申请号：
US12384391
公开号：
US08092783B2
申请日:
2009.04.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Gadolinium+3 (Gd3+) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved r1 relaxivities of 1 or 2 magnitudes higher than the commercial Gd3+-chelates as well as exceedingly, non-toxic, low release of the Gd3+ ions into an aqueous environment at a pH of about 2 to about 7.5. The Prussian blue lattice containing Gd3+ ions therein can be used for clinical diagnosis intravenously to human beings for medical imaging. The particle sizes of the doped Prussian blue lattices are of a nanosize scale and are very stable against agglomeration.
