GIJSEN, HENRICUS JACOBUS MARIA,吉森 汉瑞克斯,吉森 漢瑞克斯,MACDONALD, GREGOR JAMES,玛当诺 葛雷古,瑪當諾 葛雷古,BISCHOFF, FRANCOIS PAUL,比斯裘夫 法兰克斯,比斯裘夫 法蘭克斯,TRESADERN, GARY JOHN,翠沙登 盖瑞,翠沙登 蓋瑞,TRABANCO-SUAREZ, ANDRES AVELINO,崔班
申请号：
TW098143263
公开号：
TWI438203B
申请日:
2009.12.17
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula(I)wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2and Y3have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.本發明係有關一種新穎之式(I)經取代之二環咪唑衍生物其中R0、R1、R3、R4、X、A1、A2、A3、A4、Y1、Y2與Y3具有申請專利範圍中之定義。根據本發明化合物適用為γ分泌酶調節劑。本發明進一步有關一種製備此等新穎化合物之方法,含該新穎化合物作為活性成份之醫藥組合物,及以該化合物作為醫藥之用途。
