A compound of Formula II ** Formula ** or a stereoisomer or mixture of stereoisomers thereof, optionally in the form of a pharmaceutically acceptable salt thereof, wherein: X is NH or N (C1-C6) alkyl optionally substituted； Y is optionally substituted (C1-C6) alkylene in which up to two carbon atoms of (C1-C6) alkylene are replaced by O, NH, N-C1-C6 alkyl, -NH- (C>； = O) -, -N-(C1-C6) alkyl - (C>； = O) -, or - (C>； = O)； Q is (C1-C6) alkylene； Z is -NH- (C>； = O) - or N-(C1-C6) alkyl - (C>； = O)； R1 is halogen, hydroxy, cyano, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted (C1-C6) alkyl, optionally substituted (C1-C6) alkoxy, (C1-C6) alkyl, OH, NH2, - NH-(C1-C6) alkyl, -NH- ((C1-C6) alkyl) 2, -NH- (C>； = O) -R5, - (C>； = O) NR6R7, or -NH- (SO2) -R8； R2 is NH2, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl, R5 is H, optionally substituted (C1-C6) alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl； R6 and R7 are each independently H, optionally substituted (C1-C6) alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or R6 and R7, together with the atoms to which they are attached, they can be considered together to form an optionally substituted 3, 4, 5, 6 or 7-membered ring； R8 is optionally substituted (C1-C6) alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.Un compuesto de Fórmula II**Fórmula** o un estereoisómero o mezcla de estereoisómeros del mismo, opcionalmente en la forma de una sal farmacéuticamente aceptable del mismo, donde: X es NH o N-alqui
