AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;아주대학교산학협력단
发明人:
KIM, Moon Suk,김문석,HEO, Ji Yeon,허지연
申请号：
KRKR2018/001719
公开号：
WO2018/147660A1
申请日:
2018.02.08
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a drug delivery formulation for treating a mental illness or central nervous system disorder and, more particularly, to a drug delivery formulation for treating a mental illness or central nervous system disorder, comprising a microcapsule containing a biodegradable polymer and a drug and a crosslinked hydrogel and a method for preparing the same. A drug delivery formulation for treating a mental illness or a central nervous system disorder according to the present invention can slowly release a drug at a constant rate without a burst of drug release in the early stage of drug administration to maintain a constant blood drug level over a long period of time and thus enjoys the advantage of preventing excessive initial release of drug, which is a problem with the administration of conventional psychopharmaceutical agents or antidepressants, and easily obtaining a desirable sustained release behavior by single administration without necessity for multiple administrations divided at regular time intervals. In addition, a method for preparing a drug delivery formulation according to the present invention is a process simpler than conventional methods and has the advantage of reducing time and cost in preparing a sustained-release drug delivery formulation.La présente invention concerne une préparation d'administration de médicament pour le traitement de maladies mentales ou de troubles du système nerveux central et, plus particulièrement, une préparation d'administration de médicament pour le traitement de maladies mentales ou de troubles du système nerveux central qui comprend une micro-capsule contenant un polymère biodégradable et un médicament et un hydrogel réticulé, ainsi qu'un procédé de préparation de celle-ci. Une préparation d'administration de médicament pour le traitement de maladies mentales ou de troubles du système nerveux central selon la présente invention peut libérer lentement un médicament à un taux constant sans libé
