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Organic compounds
专利权人:
Matthias Kittelmann;Ulrich Hassiepen
发明人:
Ulrich Hassiepen,Matthias Kittelmann
申请号:
US12744510
公开号:
US08252751B2
申请日:
2008.11.25
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a compound The instant invention relates to a compound of formulae (I A), (I B), (X A), (X B), (Y A) or (Y B),wherein R′ representsand R″ represents hydrogen, hydroxy, C1-C7alkoxy, C1-C8-alkanoyloxy, or R5R4N—CO—O—, where R4 and R5 independently are C1-C7alkyl or phenyl which is unsubstituted or substituted by a substitutent selected from C1-C7alkyl, C1-C7alkoxy, halogen and trifluoromethyl and where R4 additionally is hydrogen; or R4 and R5 together represent C3-C6alkylene;in free form or in form of a pharmaceutically acceptable acid addition salt.Compounds of formulae (I A), (I B), (X A), (X B), (Y A) or (Y B) inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.
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