Unsubstituted 2-cyanopyrrolidines, pharmaceutical composition comprising them and use thereof

• 收藏
• 分享

专利权人:

NOVARTIS AG (NOVARTIS SA) (NOVARTIS INC.)

发明人:

EDWIN BERNARD VILLHAUER

申请号：

BR9915985

公开号：

BR9915985B1

申请日:

1999.12.09

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

The present invention relates to a compound of formula (I) wherein R is substituted adamantyl； and n is 0 to 3； in free form or in acid addition salt form. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/