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Organic compounds
专利权人:
Novartis AG
发明人:
Kittelmann, Matthias,Hassiepen, Ulrich
申请号:
AU2008328845
公开号:
AU2008328845C1
申请日:
2008.11.25
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention relates to a compound The instant invention relates to a compound of formulae (I A), (I B), (X A), (X B), (Y A) or (Y B), wherein R' represents (formula) and R' represents hydrogen, hydroxy, C-Calkoxy, C-C-alkanoyloxy, or RRN-CO-O-, where R and R independently are C-Calkyl or phenyl which is unsubstituted or substituted by a substitutent selected from C-Calkyl, C-Calkoxy, halogen and trifluoromethyl and where R additionally is hydrogen; or R and R together represent C-Calkylene; in free form or in form of a pharmaceutically acceptable acid addition salt. Compounds of formulae (I A), (I B), (X A), (X B), (Y A) or (Y B) inhibit DPP-IV (dipeptidyl- peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin- dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.
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