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(4-((3R,4R)-3-Methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate
专利权人:
Centrexion Therapeutics Corporation
发明人:
Markus Ostermeier,Ulrike Werthmann
申请号：
US16224902
公开号：
US20190262339A1
申请日:
2018.12.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides a salt of a tetrahydropyranylmethylaminopyrimidine amide, such as the citrate salt of (4-((3R,4R)-3-methoxytetrahydropyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone, pharmaceutical compositions containing the same, processes for preparing the same, and methods of medical treatment using the same.
来源网站：
中国工程科技知识中心
来源网址：
http://www.ckcest.cn/home/
相关专利
(4-((3R,4R)-3-METHOXYTETRAHYDRO-PYRAN-4-YLAMINO)PIPERIDIN-1-YL)(5-METHYL-6-(((2R,6S)-6-(P-TOLYL)TETRAHYDRO-2H-PYRAN-2-YL)METHYLAMINO)PYRIMIDIN-4-YL)METHANONE CITRATE
(4–((r4, r3)–3–מתוקסיטטרהידרו–פירן–4–אילאמינו)פיפרידין–1–יל(5–מתיל–6–(((s6, r2)–6–(tolyl–p) טטרהידרו h2––פירן–2–יל) מתילאמינו)פירימידין–4 יל) מתנון ציטראט
(4 - ((3R, 4R) -3-METOXYTHETRA-HYDRO-PYRAN-4-ILAMINE) PIPERIDIN-1-IL) (5- METHYL-6 - ((((2R, 6S) -6- (P- TOLIL) TETRA-HYDRO-2H-PYRAN-2-IL) METHYLAMINE) PYRIMIDIN-4-IL) METHANONE.
Crystalline hydrated form of bis [(e) - 7 - [4 - (4 - fluorophenyl) - 6 - isopropyl - 2 - [methyl (methylsulphonyl) amino] pyrimidin - 5 - yl] (3r,5s) - 3,5 - dihydroxyhept - 6 - enoic acid] calcium salt, process for its preparation, pharmaceutical compositions comprising the same and use thereof in the manufacture of a medicament for medical treatment
TREATMENT METHOD BY COMBINED USE OF MDM2 INHIBITOR AND BTK INHIBITOR
