Crystalline hydrated form of bis [(e) - 7 - [4 - (4 - fluorophenyl) - 6 - isopropyl - 2 - [methyl (methylsulphonyl) amino] pyrimidin - 5 - yl] (3r,5s) - 3,5 - dihydroxyhept - 6 - enoic acid] calcium salt, process for its preparation, pharmaceutical compositions comprising the same and use thereof in the manufacture of a medicament for medical treatment
JOHN HORBURY,JEFFREY NORMAN CRABB,REBECCA JANE BOOTH,PETER ANTHONY CITTERN,DAVID WYN CALVERT JONES
申请号：
IL17407306
公开号：
IL174073A
申请日:
2006.03.02
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
Two polymorphic forms of bis [(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6 -enoic acid] calcium salt, processes for making them and their use as HMG Co-A reductase inhibitors are described.La présente invention se rapporte à deux formes polymorphes de sel de calcium de bis[acide (E)-7-[4-(4-fluorophényl)-6-isopropyl-2-[méthyl(méthylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-énoïque], à leur procédés de production et à leur utilisation en tant quinhibiteurs de la HMG Co-A réductase.
