Disclosed is a process of preparation of formulation for treatment of Parkinsonism. The process includes dissolving 1 gm of MPTP in 9 gms by weight of distilled water to form a mother solution. The potency of mother solution is 1/10. The process further includes potentiating of the mother solution by taking 10 parts (10 minim) of mother solution and adding to it 90 parts by weight (ninety minims) of distilled water to form second solution. The process furthermore includes shaking vigorously the second solution for at least 10 minutes to forms a solution of first potency. Finally, the process includes preparing subsequent potencies with 1 part (1 minim) of the first potency solution and ninety-nine parts of dispensing alcohol and shaking the solution to form the formulation. Similar process of preparation of formulation can be employed for treatment of amyotrophic Lateral Sclerosis (commonest form of MND).