VAN DER WONING, SEBASTIAN,BORGIONS, FILIP,DREIER, TORSTEN,MARIEN, LORE,DE BOECK, GITTE,LIENART, STEPHANIE,LUCAS, SOPHIE,COULIE, PIERRE
申请号：
CA3061841
公开号：
CA3061841A1
申请日:
2018.05.11
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to antibodies and antigen binding fragmentsthereof, which bind to a complex of GARPand TGF-.beta.1, particularly a complex of human GARP and human TGF-.beta.1.These antibodies and antigen binding fragments exhibit acombination of advantageous properties including high affinity antigen bindingand the ability to inhibit the release of active TGF-.beta.from regulatory T cells. The antibodies and antigen binding fragments of thepresent invention are relatively resistant to deamidation,isomerization and oxidation, such that they display improved stability.
