Sebastian Van der Woning,Filip Borgions,Torsten Dreier,Lore Mariën,Gitte De Boeck,Stéphanie Liénart,Sophie Lucas,Pierre Coulie
申请号：
US15977449
公开号：
US10479829B2
申请日:
2018.05.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.
