VAN DER WONING, Sebastian,BORGIONS, Filip,DREIER, Torsten,MARIEN, Lore,DE BOECK, Gitte,LIENART, St‚phanie,LUCAS, Sophie,COULIE, Pierre
申请号：
PH12019502526
公开号：
PH12019502526A1
申请日:
2019.11.11
申请国别(地区):
PH
年份:
2020
代理人:
摘要：
The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-á1, particularly a complex of human GARP and human TGF-á1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-á from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.
