PROCÉDÉ DE PRODUCTION DE MEMBRANE DE MATRICE EXTRACELLULAIRE OBTENUE À PARTIR DE CARTILAGE PORCIN BIOCOMPATIBLE CAPABLE DE RÉGULER UN TAUX DE DÉCOMPOSITION IN VIVO ET DES PROPRIÉTÉS PHYSIQUES, ET COMPOSITION POUR PRÉVENIR UNE ADHÉRENCE CONTENANT UNE MATRICE EXTRACELLULAIRE OBTENUE À PARTIR DE CARTILAGE PORCIN COMME PRINCIPE ACTIF
MIN, Byoung-Hyun,KIM, Young Jick,SONG, Bo Ram,YUN, Hee Woong,JEONG, Sung In,LIM, Youn-Mook,PARK, Jong-Seok,GWON, Hui-Jeong
申请号：
EP17763589
公开号：
EP3427765A4
申请日:
2017.03.09
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a method for preparing a biocompatible porcine cartilage-derived extracellular matrix membrane capable of adjusting an in-vovo degradation rate and a mechanical property, and a composition containing the porcine cartilage-derived extracellular matrix as an active ingredient, for preventing adhesion between tissues and/or organs. Despite its high biocompatibility as a natural material, cartilage tissue extracellular matrix has a short decomposition period and its mechanical property is weak, thereby restricting the application. Accordingly, a method of enhancing the mechanical property through physical or chemical treatment and radiation treatment has been developed. In the present invention, biomaterials of various formulations were produced by treating the porcine cartilage-derived extracellular matrix with physiochemical methods. In addition, although was carried out, a characteristic that the above cartilage-specific function was maintained despite the treatment of the physico-chemical treatment was checked. Furthermore, it may also be used as an adhesion inhibitor with excellent in-vivo stability and anti-adhesion effect by using the porcine cartilage-derived extracellular matrix material.
