A process for preparing duloxetine and intermediates for use therein

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专利权人:

发明人:

申请号：

EP06075798.6

公开号：

EP1690861B1

申请日:

2003.12.10

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

A process for making (+)duloxetine or an acid addition salt thereof, comprising reacting intermediate compounds of formulae (I) and (II) so as to yield a compound of formula (III), or an acid addition salt thereof in the presence of a base and a phase transfer catalyst, where one of X and Y is hydroxy and the other is a leaving group, and subjecting a compound of formula (III), or an acid addition salt thereof, to further process steps so as to yield (+) duloxetine, or an acid addition salt thereof, substantially free of (-)duloxetine.

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中国工程科技知识中心

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