Francesco Velardi;Elena Barbanti;Tiziano Ruffilli;Patricia Salvati;Carla Caccia;Luigi Bogogna
发明人:
Elena Barbanti,Carla Caccia,Patricia Salvati,Francesco Velardi,Tiziano Ruffilli,Luigi Bogogna
申请号：
US13288891
公开号：
US08278485B2
申请日:
2011.11.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight.The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent.
