A method for acquiring and processing image data of an examination object is provided. A three-dimensional bone model and a three-dimensional blood vessel model are provided. A two-dimensional, first X-ray image and a two-dimensional, second X-ray image of the examination region are acquired having a same image geometry. The first X-ray image is subtracted from the second X-ray image to provide a subtraction image. A first intermediate registration of the first X-ray image is determined in relation to the bone model, and a second intermediate registration of the subtraction image is determined in relation to the blood vessel model. A transformation function that images the first intermediate registration onto the second intermediate registration is determined. A third X-ray image of the examination region is acquired. A bone registration of the third X-ray image in relation to the bone model is determined.
