A process for preparing duloxetine and intermediates for use therein

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专利权人:

Cipla Limited

发明人:

Rao, Dharmaraj Ramachandra,Kankan, Rajendra Narayanrao

申请号：

AU2010200142

公开号：

AU2010200142B2

申请日:

2010.01.14

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2010200142B220120412.pdf#####ABSTRACT A PROCESS FOR PREPARING DULOXETINE AND INTERMEDIATES FOR USE THEREIN A process for preparing (+)duloxetine, or an acid addition salt thereof, which process comprises resolving racemic (±)duloxetine with a chiral acid so as to obtain a salt of the chiral acid and (+)duloxetine, substantially free of (-)duloxetine； and (ii) if desired, converting the salt prepared in step (i) to the free base or another acid addition salt as appropriate. The process for preparing (+)duloxetine, or an acid addition salt thereof, can further comprise an 0-alkylation intermediate process step which is carried out in the presence of a base and a phase transfer catalyst. 2163192_1 (GHMalters)

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