FREIRE, ANA CRISTINA,BASIT, ABDUL WASEH,BRAVO GONZALEZ, ROBERTO CARLOS,VARUM, FELIPE JOSE OLIVEIRA,BUSER, THOMAS
申请号：
PE2016000264
公开号：
PE20160211A1
申请日:
2013.10.29
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
In the formulation of delayed release, including a nucleon containing drug and a coating of delayed release to provide intestinal release, pharmacy release in colon is accelerated by incorporating an insulating layer into the core and coating of delayed release. The delayed release coating consists of an inner and an outer layer. The surface layer includes soluble polygonal material at a pH threshold of about pH 5 or higher. The inner layer is composed of a soluble polygonal substance, which can be dissolved in intestinal fluid or gastrointestinal fluid,The soluble polygonal substance is selected from a group consisting of at least partially neutralized polygonal acid polymer and a non ionized descendant polymer, provided that when the soluble polygonal substance is a non ionized descendant polymer, the inner layer contains at least one additive selected from the pH regulator. There's another baseEn una formulacion de liberacion retardada que comprende un nucleo que contiene un farmaco y un recubrimiento de liberacion retardada para proporciona la liberacion intestinal, la liberacion del farmaco en el colon se acelera mediante la inclusion de una capa aislante entre el nucleo y el recubrimiento de liberacion retardada. El recubrimiento de liberacion retardada comprende una capa interior y una capa exterior. La capa exterior comprende material polimerico soluble con dependencia del pH que tiene umbral de pH a aproximadamente pH 5 o mas alto. La capa interior comprende un material polimerico soluble que es soluble en el fluido intestinal o fluido gastrointestinal, tal material polimerico soluble se selecciona del grupo que consiste de a un polimero de acido policarboxilico que esta al menos parcialmente neutralizado, y un polimero no ionico, siempre que, cuando tal material polimerico soluble sea un polimero no ionico, la capa interior comprende al menos un aditivo seleccionado de un agente regulador de pH y una base.
