FREIRE, ANA CRISTINA,BASIT, ABDUL WASEH,BRAVO GONZALEZ, ROBERTO CARLOS,VARUM, FELIPE JOSE OLIVEIRA,BUSER, THOMAS
申请号：
PE0002642016
公开号：
PE02112016A1
申请日:
2013.10.29
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
In a delayed Release formulation comprising a Core containing a Drug and a release Coating provides for delayed Release intestinal Drug release in the colon is Accelerated by including an Insulating layer between the core and the recubrimi This delayed release.The delayed Release Coating comprises an inner layer and an outer layer. The outer layer includes soluble polymeric material with pH dependence that has Threshold pH to approximately pH 5 or higher.The Inner Layer comprises a soluble polymeric material which is Soluble in the gastrointestinal intestinal Fluid or Fluid, soluble Polymer Material selected from the group consisting of a Polymer policarboxilico acid is at least partially neutralized, and a Polymer didnt Nico, provided that when such soluble polymeric material is a nonionic Polymer,The Inner Layer comprises at least one Additive selected from a pH Regulating Agent and a base.En una formulacion de liberacion retardada que comprende un nucleo que contiene un farmaco y un recubrimiento de liberacion retardada para proporciona la liberacion intestinal, la liberacion del farmaco en el colon se acelera mediante la inclusion de una capa aislante entre el nucleo y el recubrimiento de liberacion retardada. El recubrimiento de liberacion retardada comprende una capa interior y una capa exterior. La capa exterior comprende material polimerico soluble con dependencia del pH que tiene umbral de pH a aproximadamente pH 5 o mas alto. La capa interior comprende un material polimerico soluble que es soluble en el fluido intestinal o fluido gastrointestinal, tal material polimerico soluble se selecciona del grupo que consiste de a un polimero de acido policarboxilico que esta al menos parcialmente neutralizado, y un polimero no ionico, siempre que, cuando tal material polimerico soluble sea un polimero no ionico, la capa interior comprende al menos un aditivo seleccionado de un agente regulador de pH y una base.
